Polynucleotides Regenerative Treatments
Before and after photos
Polynucleotides - latest regenerative skin treatments
What are regenerative treatments (polynucleotides)?
Polynucleotides are a newly emerging trend in anti-ageing injections that stimulate tissue repair and encourage restoration and regeneration of the skin from within. They can be used in a wide range of applications as a rejuvenating treatment for older skin and as a preventative treatment for younger skin.
Polynucleotides (full name polydeoxyribonucleotides) are long chains of nucleotides that make up DNA and RNA molecules. They are derived from fragments of fish DNA (which resemble human DNA), which means they have the ability to function as a biostimulator, kick-starting regeneration in the skin. Not only are they anti-inflammatory, thanks to their antioxidant properties, but they increase collagen production, resulting in a thicker, healthier epidermis.
Regenerative treatments (polynucleotides) also include mesotherapy.
Benefits of polynucleotides
Research shows that polynucleotides can increase collagen by up to 47% in 23 days and help create a thicker, healthier epidermis with improvements of 52% in 23 days. With a range of applications, the benefits of polynucleotides include:
- Stimulating the production of collagen and elastin, which helps to improve skin elasticity and firmness, enhancing the results of other treatments, as well as reducing the appearance of wrinkles and sagging skin
- Reducing inflammation, restoring volume and hydration to the skin
- Helping to protect the skin from damage caused by the sun
- Little downtime compared to other injectables
Polynucleotides treatment applications
Polynucleotides are being used to reverse the ageing of tissues and repair scarring by tackling the concern from the source, in contrast to the traditional approach, for example with fillers, which focuses on treating symptoms. Some of the applications of polynucleotides include:
- Rejuvenating treatment for older skin to treat fine lines and wrinkles
- Preventative treatment for younger skin
- Rehydration for dull skin at any age
- Treating dark circles as an alternative to tear trough fillers
- Strengthening delicate areas of skin such as around the eyes and mouth
- Reducing inflammation to helps with conditions such as rosacea
- Treating hyperpigmentation, sun damage, scarring, stretch marks and acne
- Treating alopecia and hair loss
In addition to their success rate with these applications, polynucleotides work well alongside other treatments, enhancing their effects, such as by boosting the longevity of anti-wrinkle injections.
Treatment Time
15 - 30 minutes
Recovery Time
Same day
Results
2-3 days
Results Duration
3-6 months
Polynucleotides Treatment Costs
| Polynucleotides Treatment | Cost per session |
|---|---|
| 1x single PhilArt polynucleotides treatment session | £395 |
Consultation
The cost of consultation with our doctors is £75. This is redeemable against the cost of treatment carried out on the same day.
Prices are a guide to the costs and the exact price can only be determined once the doctor has examined you in person.
Call 0207 386 0464 OR email enquiries@cosmedics.co.uk for advice and help.
An insight into treatment at Cosmedics
Meet your medical team
MBBS
FEBOPHTH L7CERT(AESTH)
BSc(hons), MBChB, MRCS
MBBS(Lond) BMedSci MRCS(Eng) FRCS(Plast)
MBBS, FRCS(Plast)
MBBS PhD
MBChB
MBBS
MD
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Polynucleotides FAQ
Is polynucleotide a filler?
Polynucleotides don’t contain hyaluronic acid like fillers do. Instead, they are comprised of biopolymers DNA (deoxyribonucleic acid) and RNA (ribonucleic acid) . In DNA there are two spiral chains of polynucleotide which are arranged in a helical fashion, while RNA is a single-stranded molecule.
What happens during a polynucleotides treatment?
Before the treatment a numbing cream can be applied to the patient, especially if there are multiple injections involved. Depending on the area of treatment, the polynucleotides can be injected via two methods. The first are very tiny needles, leaving tiny blebs on the surface which disappear usually after a few hours. Alternatively, a blunt-ended cannula may be used to spread the product evenly. The process usually takes about 20-30 minutes.
How long do polynucleotides treatment results last?
Results last around six to nine months on average, depending on the patient’s lifestyle and rate of ageing.
What are the potential complications, risks and side effects of polynucleotides?
The risks of polynucleotides are less than those of other injectable procedures, but this will depend on the practitioner’s experience and technique. However, unlike dermal filler, the treatment cannot be reversed as the product can’t be dissolved.
Side effects of polynucleotides are generally minimal, with the main potential side effects relating to the site of the injection, where patients may experience redness, swelling and bruising which should settle after one to two days. More serious side effects, such as allergic reactions, are extremely rare. As with all treatments, it’s important to carry out a thorough pre-treatment consultation to assess the patient’s suitability.
How quickly will I see results after polynucleotides treatment?
Unlike with dermal fillers, which have an instant effect, patients won’t notice the full benefits with polynucleotides immediatlely. This is because the action is at the cellular level and it takes time to become apparent, but patients may see some improvement after two to three weeks.
Who should not have polynucleotides?
Although polynucleotides are well tolerated by most patients and are suitable for all skin types, including sensitive skin, they are derived from fish, therefore are not appropriate for vegans. Allergic reactions are very unlikely as the particles of DNA are highly purified, so it can be safely injected into those who have allergies, including seafood allergies, with clinical trials reporting no allergic reactions to date. Polynucleotides are not suitable for patients who are pregnant or intending pregnancy, or who are breastfeeding.
How long does it take to recover from polynucleotides treatment?
Patients can generally return to normal activities straight after treatment.
In terms of aftercare, no makeup is advised for 12 hours and no laser treatments or excess heat for three weeks. SPF should be applied strictly for two to three weeks, and sunlight avoided.
References
- Bartoletti E, Cavallini M, Maioli L, Massirone A, Palmieri IP, Papagni M et al. Introduction to Polynucleotides Highly Purified Technology. Aesthetic Medicine. 2020 Oct-Dec; Vol.7 (1): 43-47.
- Collangelo MT. Govoni P, Beletti s, Squadrito F, Guizzardi S, Galli C. Polynucleotide biogel enchances tissue repair, matrix desposition and organization. J. of Biological Regulators & Homeostatic Agents. 2021; Vol.35 (1): 355-362.
- Cavallini M, Bartoletti E, Maioli L, Massirone A, Pia Palmieri I, Papagni M et al. Consensus report on the use of PN-HPT (polynucleotides highly purified technology) in aesthetic medicine. J CosmetDermatol. 2021 Mar. 20 (3): 922-928. doi: 10.11.11/jocd.13679. Epub 2020 Sept. 21. PMID: 32799391; PMCID: PMC7984045.
- Cavallini M, Papagni M. Long Chain Polynucleotides Gel and Skin Biorevitalization. International Journal of Plastic Dermatology-ISPLAD. 2007; 3 (3): 27-32.
- Massirone A. Polynucleotides Highly Purified Technology and the face skin, a history of innovative skin priming. Aesthetic Medicine. 2021 Jan-Mar; Vol. 7 (1): 25-40.
- Araco A, Araco F. Preliminary Prospective and Randomized Study of Highly Purified Polynucleotide vs Placebo in Treatment of Moderate to Severe Acne Scars. Aesthet Surg J. 2021 Jun. 14; 41
- NP866-NP874. doi: 10.10.93/asj/sjab125. PMID: 33755110. PADB1222IMCAS | 38942 Product information for healthcare professionals CE0373 PRKIT0123a